Aims : Much of pulmonary medicine is moving towards personalised treatment that is based on the specific patient’s phenotype. In lung cancer, tumours are targeted on the basis of their genetic signature. In asthma, biological agents are selected on the basis of circulating inflammatory markers. By contrast, in COPD, there has been very little development in terms of personalised therapy. However, interventional procedures are leading the way towards personalised solutions for specific COPD subtypes. On the basis of imaging and other tools, experts can now identify the most likely responders to specific interventions for emphysema. Moreover, we may soon have procedures for other COPD phenotypes, such as cryoablation for chronic bronchitis patients with a high mucous production, or radiofrequency ablation for frequent exacerbators with chronic cough. This session will educate participants about the latest scientific data and make recommendations about how to phenotype and differentially treat advanced COPD patients with non-pharmacological interventions.