Aims : To disseminate the latest scientific advances in pulmonary rehabilitation and non-pharmacological management strategies for patients with diffuse parenchymal lung diseases (DPLDs), with updates describing improved outcomes and survival and the efficacy of pharmacological treatments and transplantation strategies; to analyze the physiological basis of the effectiveness of exercise training by determine the most appropriate outcome measures to evaluate the efficacy of pulmonary rehabilitation (PR) in these subjects; to describe the most relevant non-pharmacological interventions (e.g.: oxygen therapy, dyspnoea and cough management, acute care of exacerbations, and palliation) designed to minimise the impact of DPLDs on patients, families and carers; and to provide practical recommendations for a multidisciplinary approach to patients with DPLDs.