ERS International Congress 2022 - Thematic poster Identifying therapeutic targets and novel drug strategies in pulmonary diseases

Airway diseases

Interstitial lung diseases

Thoracic oncology

Thematic poster

Identifying therapeutic targets and novel drug strategies in pulmonary diseases

Methods : Imaging, Pulmonary function testing, Cell and molecular biology

Chairs

London (United Kingdom)

Bern (Switzerland)

scRNA sequencing on human airway epithelium reveals metabolic changes during healthy aging P. Prabhala(Lund, Sweden)

Identify Bcl3 as a novel biomarker shared between severe asthma and lung cancer using next-generation RNA sequencing from archival FFPE tissue biopsies L. Salameh(Dubai, United Arab Emirates)

Identification of miR-328-3p targets during wound repair of bronchial epithelial cells B. Narozna(Poznań, Poland)

Correction of structural changes of lung parenchyma in induced systemic sclerosis B. Doskaliuk(Ivano-Frankivsk, Ukraine)

Hyaluronic acid-targeted metabolism in Acute Respiratory Distress Syndrome F. Zamboni(Limerick, Ireland)

GTX-003 reduces the fibrotic markers in human lung fibroblast from patients with interstitial lung diseases. A. Montes Worboys(Sevilla, Spain)

Extracellular matrix formation reduction by nintedanib varies in the Scar-in-a-Jar fibroblast model depending on pathway induction J. Sand(Herlev, Denmark)

Delayed Treatment with the Novel HSP90 inhibitor TAS-116 Ameliorate Hydrochloric Acid-Induced Pulmonary Fibrosis P. Solopov(Norfolk, United States)

Antifibrotic effect of metformin in a rat double-hit bleomycin model M. Bonatti(Solna, Sweden)

Targeting p16 to induce Krt8+ transitional stem cell state and promote alveolar regeneration B. Ribeiro Baptista(Nancy, France)

Inhibition of neutrophilic inflammation by targeting the airway epithelial barrier with EP395. J. Kricker(Reykjavík, Iceland)

Short chain fatty acids reduce inflamm-aging and ameliorate enhanced severity of acute lung injury in old mice C. Hildebrand(Hannover, Germany)

Omeg@Silica microencapsulated fish oil counteracts tumor-related inflammation in lung adenocarcinoma cells E. Pace(Palermo (PA), Italy)

Effect of dipeptidyl peptidase-4 inhibitor on emphysema model in mice H. Joo(Seoul, Republic of Korea)

KVX-053, a PTP4A3 inhibitor, as antidote against CEES-induced Acute Lung Injury R. Colunga Biancatelli(Norfolk, United States)

Mesenchymal Stromal Cells Modulate the Immune Cell Response in a Klebsiella Pneumoniae Induced Sepsis Model J. Brady(Galway, Ireland)

Late Breaking Abstract - Airway morphogenesis in wild type and heterozygous F508del mouse embryonic lungs treated by Elexacaftor/Tezacaftor/Ivacaftor A. Hadchouel-Duvergé(Paris, France)

Late Breaking Abstract - CFAP74-mutations as cause of Primary Ciliary Dyskinesia (PCD): Clinical presentation and diagnostic challenges L. Biebach(Münster, Germany)